A novel label-free electrochemical immunosensor based on functionalized nitrogen-doped graphene quantum dots for carcinoembryonic antigen detection Original Research Article Biosensors and Bioelectronics, Available online 15 November 2016, Pages Yuying Yang, Qing Liu, Yan Liu, Jianjian Cui, Hui Liu, Ping Wang, Yueyun Li, Lei Chen, Zengdian Zhao, Yunhui Dong | Fabrication and current-voltage characteristics of Mo1-xWxS2/graphene oxide heterojunction diode Original Research Article Surface and Coatings Technology, Available online 15 November 2016, Pages Wei-Jhih Su, You-Li Wang, Wan-Siang Gan, Yi-Ping Wang, Hung-Pin Hsu, Shin-ichi Honda, Pao-Hung Lin, Ying-Sheng Huang, Kuei-Yi Lee | Acoustic cavitation induced generation of stabiliser-free, extremely stable reduced graphene oxide nanodispersion for efficient delivery of paclitaxel in cancer cells Original Research Article Ultrasonics Sonochemistry, Available online 15 November 2016, Pages Renu Geetha Bai, Kasturi Muthoosamy, Fiona Natalia Shipton, Sivakumar Manickam
Graphical abstractImportance of this Investigation: Graphene is getting popular day-by-day due to its novel properties and technological applications in different fields. Due to its hydrophobic nature, generation of stable aqueous dispersion of reduced graphene oxide (RGO) becomes difficult without using any stabilizing agents, which may affect and alter the properties. In this investigation RGO is synthesised in an eco-friendly strategy by limiting the use of harsh chemicals and the aqueous dispersion of RGO has been generated by employing ultrasonic cavitation. The developed RGO dispersion is exceedingly stable for more than the tested period of 2 years. This ultrasound strategy completely excludes the addition of any chemicals to enhance the stability of aqueous RGO dispersion. The chemical-free and stabilizer-free RGO dispersion generated through this strategy was then utilized to obtain a nanodrug delivery system for an anti-cancer drug, Paclitaxel (Ptx). The RGO-Ptx nanodrug system was then tested against both cancer and normal cell lines to analyze its cytotoxic effects. Upon MTT assay, the RGO-Ptx drug delivery system was found to be specifically toxic only towards cancer cells and is biocompatible towards normal cells, and thus offers a promising future for RGO in the development of novel drug delivery systems.
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