Synergistic antibacterial effects of localized heat and oxidative stress caused by hydroxyl radicals mediated by graphene/iron oxide-based nanocomposites Original Research Article Nanomedicine: Nanotechnology, Biology and Medicine, Available online 19 December 2015, Pages Wen-Yu Pan, Chieh-Cheng Huang, Tzu-Tsen Lin, Hsin-Yi Hu, Wei-Chih Lin, Meng-Ju Li, Hsing-Wen Sung
Graphical abstractA nanocomposite system of reduced graphene oxide-iron oxide nanoparticles (rGO-IONP) is synthesized for achieving synergetic effects in doing physical and chemical damage to methicillin-resistant Staphylococcus aureus (MRSA). The rGO efficiently absorbs near infrared (NIR) energy and converts it to localized heat, doing physical damage to bacteria. The IONP catalyzes the degradation of H2O2, whose level is markedly elevated by local inflammation, to form highly reactive •OH radicals via Fenton reactions, chemically damaging MRSA. The in vivo results suggest that combined treatment with rGO-IONP + NIR effectively inactivates the bacteria in subcutaneous abscesses and accelerates wound healing.
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